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In response to the dire social and economic consequences predicted to result from climate change—especially for the most vulnerable populations in developing countries— policy makers around the world are working toward a new long-term international framework to address this global challenge. Asia and the Pacific has the world’s most dynamic economies but also the greatest number of people at risk from climate change as well as the fastest-growing emissions of greenhouse gases (GHGs)—the cause of global warming. Unless Asia and the rest of the world act to stabilize GHG emissions, poverty reduction efforts will experience new threats from climate-induced risks to the health, safety, and productivity of the poor. Such impacts are already affecting populations across the region, so even with aggressive actions, measures are needed to protect the most vulnerable from the adverse effects of sea level rise, melting glaciers, more frequent and severe climate-related natural disasters, greater variability of rainfall, and other predicted consequences of climate change.